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Prospective roles for miRNAs during embryonic gonad development when you look at the chicken

AMH sign transduction via the TGF-Я signalling path and possible involvement of miRNAs.

AMH binds specifically towards the AMH receptor (AMHR2), which activates either activin receptor 1 (ACVR1), or bone tissue morphogenic receptor 1A (BMPR1A), or 1B (BMPR1B). Activated ACVR1 and BMPR1A transduce AMH signals by activating SMAD proteins that are signallingSMAD1, 5 or 8), with the help of ZEB1. BMPR1B competitively antagonises SMAD activation. TGIF and ZEB2 bind to SMADs and SMAD DNA binding sites, correspondingly, to prevent signalling. MiR-101 ( red) is predicted to a target BMPR1B, ZEB1 and 2, and TGIF transcripts, and may also modulate TGF-Я signalling. miR-202-5p and miR-31 ( red) are predicted to a target ACVR1 and SMAD5, and BMPR1A transcripts, correspondingly, and may also help a shifting TGF-Я signalling paths in men post-gonadal intercourse differentiation

Interestingly, miR-101 is predicted to focus on TGIF1, ZEB2 and BMPR1B (TargetScan, Lewis et al. 2005 ), which inhibit TGF-Я signalling.

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